Impacts of morphine addiction on spermatogenesis in rats

Background: There are numerous investigations on wide range of issues that disrupt regulatory spermatogenesis, individuals who are exposed to drug abuse faced infertility and immature spermatogenesis

Objective: The aim of this study was to evaluate the addiction effects of morphine and its derivatives on rats spermatogenesis

Materials and Methods: 40 male Wistar rats were randomly divided into 5 equal groups, which were exposed either with intravenous morphine, naloxone, naloxone and morphine, sham [with normal saline injection] and a control group without infusion. Spermatogenesis was assessed after three months via histological sections with hematoxylin and eosin staining, using a light microscope based on measurement of spermatogonia, spermatocyte, spermatid, and spermatozoa

Results: Those rats that received opioids had changes in spermatogenesis function. The population of spermatogenesis cycle cells at spermatogonia, spermatocyte, spermatid, and spermatozoa stages was significantly decreased in those rats that received opioid in comparison to the control group [p<0.05]. Histological studies revealed that changes in different groups of opioid application might affect sperm formation. Sperm count in morphine group was [0+/-0] and in naloxone group, naloxone+morphine, sham and control were 235+/-3.77, 220+/-3.81, 247.12+/-6.10 and 250+/-6.54, respectively [p<0.001]

Conclusion: Morphine could affect all spermatogenesis stages

prevalence of magnetic resonance imaging hyperintensity in migraine patients and its association with migraine headache characteristics and cardiovascular risk factors

To determine the frequency of hyperintense foci in migraine patients and the relationship with migraine headache characteristics and cardiovascular risk factors. Ninety patients with migraine headache [70 without aura and 20 with aura] were enrolled and interviewed. Information on their headache [severity, frequency, and mean disease duration] and other related data was obtained by completing a clinical checklist. Subsequently, brain magnetic resonance imaging [MRI] was performed and each patient was then evaluated for hyperintense lesions. Of the 90 patients, 29 [32%] had silent hyperintense lesions on their MRI. The mean age of the patients with hyperintense foci was 41 years while those with no lesions was 33 years [p<0.010]. Supratentorial hyperintense lesions represented the majority of lesions in the patients [n=46, 63%]. Moreover, 56.3% of the lesions [n=41] were located within the right hemisphere. Cardiovascular risk factors such as smoking, serum cholesterol, oral contraceptive pills use, and body mass index [BMI] were not significantly different in these two groups [p>0.050]. The lesions were found significantly more frequently in the patients who experienced chronic migraine [p=0.032]. Our study adds weight to the theory that disease duration has a key role in the formation of hyperintense brain lesions. Certain cardiovascular risk factors such as sex, smoking, serum cholesterol, and BMI, do not affect the presence or absence of such lesions, suggesting that the relationship between migraine and these lesions may be directly due to the effects of migraine itself

Sleep-related eating disorder: a case report of a progressed night eating syndrome

Night eating syndrome is a common disorder in eating behaviors that occurs in close relation to the night time sleep cycle. Although eating disorders are common in society, night eating syndrome has been left neglected by health care professionals. In this report we present a case of eating disorder that exhibits some novel features of night eating syndrome. Our case was a progressed type of eating disorder which may increase awareness among physicians about sleep-related eating disorders.

Cerebral sinovenous thrombosis [CSVT] in a neonate with different manifestations

Cerebral sinovenous thrombosis [CSVT] is increasingly diagnosed in neonates. Despite many studies which have addressed diagnosis and management of pediatric CSVT, diagnosis of CVSD in neonates is difficult. A female neonate born by natural vaginal delivery was diagnosed with CSVT after initiation of seizure. The seizure was stabilized and after performing diagnostic tests, the diagnosis of CSVT was made. This report describes diagnosis of this rare condition in a newborn baby in order to make awareness about this serious condition in neonates